Metaraminol

Metaraminol is a sympathomimetic amine that acts as a potent vasoconstrictor. It is primarily used to increase blood pressure in cases of severe hypotension or shock. By stimulating alpha-adrenergic receptors, metaraminol causes vasoconstriction, leading to an increase in systemic vascular resistance and blood pressure.

Indications

Metaraminol is indicated for the treatment of severe hypotension or shock, particularly in situations where other measures have failed to adequately increase blood pressure.

Dosage

The dosage of metaraminol varies depending on the patient's age, weight, and medical condition. It is usually administered intravenously, with the dosage titrated to achieve the desired increase in blood pressure while minimizing adverse effects.

Contra-Indications

Metaraminol is contraindicated in patients with hypersensitivity to the drug, as well as in those with severe hypertension, peripheral vascular diseases, or hyperthyroidism.

Special Precautions

Special precautions should be taken when administering metaraminol to patients with cardiovascular diseases, including angina, arrhythmias, or ischemic heart disease. Close monitoring of blood pressure and heart rate is essential during treatment.

Side Effects

Common side effects of metaraminol include hypertension, tachycardia, headache, palpitations, nausea, and vomiting. Rare but serious side effects may include myocardial ischemia, cardiac arrhythmias, and tissue necrosis at the injection site.

Drug Interactions

Metaraminol may potentiate the effects of other sympathomimetic drugs, such as adrenaline and noradrenaline. Concurrent use with monoamine oxidase inhibitors (MAOIs) may lead to hypertensive crisis.