QUINIODOCHLOR

Quiniodochlor (also known as clioquinol) is a halogenated hydroxyquinoline derivative with antibacterial and antifungal properties. It is primarily used topically and occasionally orally in the treatment of protozoal infections, fungal skin conditions, and certain gastrointestinal disorders.

Indications

- Amoebiasis (intestinal) - Giardiasis - Fungal infections of the skin (e.g., dermatophytosis, candidiasis) - Vaginitis caused by mixed infections - Diarrhea caused by protozoa (limited use due to neurotoxicity concerns)

Dosage

- Apply a thin layer to the affected area 2–3 times daily or as directed by a physician. Oral (rare and restricted use): - Adults: 250–500 mg orally, three times daily for up to 20 days - Children: Dosage to be determined by physician based on age and weight

Contra-Indications

- Known hypersensitivity to Quiniodochlor or related compounds - Pre-existing optic neuritis or other optic nerve disorders - Severe hepatic or renal impairment - Prolonged oral use or high doses

Special Precautions

- Avoid long-term oral use to reduce the risk of neurotoxicity. - Monitor for signs of optic nerve damage (e.g., vision changes, color vision loss). - Not recommended during pregnancy or breastfeeding unless absolutely necessary. - Use with caution in elderly patients and those with preexisting neurological conditions.

Side Effects

- Topical: Skin irritation, rash, itching, staining of the skin or clothes - Oral (rare use): Nausea, diarrhea, headache, optic neuritis, peripheral neuropathy, Subacute Myelo-Optic Neuropathy (SMON)

Drug Interactions

- May interact with other neurotoxic drugs, increasing the risk of neuropathy - Risk of additive irritation when used with other topical irritants - Concomitant use with iodine-containing medications should be avoided