Methylcobalamin

Methylcobalamin is a form of Vitamin B12, which is essential for maintaining the health of nerve cells and aiding in the production of DNA and red blood cells. Unlike other forms of Vitamin B12, Methylcobalamin is a coenzyme, making it more bioavailable and active in the body. It is a kind of endogenous coenzyme B12. Mecobalamin plays an important role in transmethylation as a coenzyme in the synthesis of methionine from homocysteine. Mecobalamin is well transported to nerve cell organelles, and promotes nucletic acid and protein synthesis.

Indications

-Treatment of Vitamin B12 deficiency -Support for neurological health -Management of pernicious anemia -Adjunct therapy for neuropathies such as diabetic neuropathy and peripheral neuropathy

Dosage

-1,500mcg of Mecobalamin daily divided into three doses, for a period of minimum 2 month. The dosage may be adjusted depending on the patient's age and symptoms. -The typical dosage ranges from 500 mcg to 5000 mcg per day, depending on the severity of the deficiency and patient needs. -For neuropathy, doses may be higher, as prescribed by a healthcare provider.

Contra-Indications

-Hypersensitivity to Methylcobalamin or any component of the formulation -Leber’s disease (hereditary optic nerve atrophy), as it may cause severe optic atrophy in individuals with this condition

Special Precautions

-Monitor blood levels regularly to avoid hypervitaminosis -Use with caution in patients with kidney disease -Pregnant and breastfeeding women should consult a healthcare provider before use

Side Effects

Gastrointestinal adverse drug reactions included anorexia, nausea, vomiting and diarrhoea. Rarely hypersensitivity reactions like rash may occur.

Drug Interactions

-Chloramphenicol may reduce the hematologic response to Methylcobalamin -Proton pump inhibitors (PPIs) and H2 receptor antagonists can reduce the absorption of Vitamin B12 -Metformin may decrease the absorption of Methylcobalamin