Ofloxacin

Indications

Genito urinary, respiratory, Gastro-intestinal, Skin & Soft tissue infections. Peritonitis, Gonorrhoea.

Dosage

Adults: 200-400mg daily usually for 5-7 days depending on type and severity of infection. Doses greater than 400 mg should be given in 2 divided doses. Urinary tract infection : 200-800mg daily lower respiratory tract infection : 400-800mg daily Gonorrhoea: 400mg as a single dose. Not recommended for children.

Contra-Indications

Hypersensitivity to 4-quinolones. History of epilepsy.

Special Precautions

Exposure to strong sun light and ultra violet rays should be avoided. Driving or operating machinery. Renal insufficiency, Psychiatric disorders concomitant use of aluminium and magnesium containing antacids. Paediatrics: Safety not established in children below 16 years. Pregnancy: Contraindicated. Lactation: Contraindicated. Elderly: Safe.

Side Effects

Hypersensitivity reactions,skin reactions, CNS disturbances,G.I upset pseudomembranous colitis.Transient increase in liver enzymes. Rarely, joint /muscle pain,bone marrow depression.

Drug Interactions

Antacids containing magnesium and aluminium reduce absorption. Sucralfate reduces absorption. Inhibits GABA receptor binding. Probenecid decreases elimination.