Cefixime

Cefixime is a broad-spectrum cephalosporin antibiotic used to treat various bacterial infections. It works by inhibiting the synthesis of bacterial cell walls, leading to the death of the bacteria.

Indications

-Acute bacterial sinusitis -Acute otitis media -Pharyngitis and tonsillitis -Urinary tract infections -Gonorrhea

Dosage

-Adults: Typically 400 mg daily, either as a single dose or divided into two doses. -Children: Dosage is usually based on body weight. Commonly, 8 mg/kg per day, either as a single dose or divided into two doses.

Contra-Indications

-Allergy to cephalosporins or penicillins -Severe renal impairment (adjust dosage or avoid use)

Special Precautions

-Monitor renal function in patients with pre-existing kidney conditions. -Use with caution in patients with a history of gastrointestinal disease, particularly colitis.

Side Effects

-Gastrointestinal disturbances (nausea, diarrhea) -Allergic reactions (rash, itching) -Headache -Dizziness

Drug Interactions

-May reduce the effectiveness of oral contraceptives. -May increase the risk of bleeding when used with anticoagulants. -Probenecid can increase Cefixime levels in the blood.