Flurbiprofen sodium

It is one of a series of phenylalkanoic acid that have shown anti-inflammatory activity it inhibitis cyclo-oxygenase enzymes essential in the biosynthesis of prostaglandins, which are mediator of certain kinds of intraocular inflammatory processes. Prostaglandis appear to play a role in the miotic response produced during ocular surgery by condtricting the iris sphincter independently of cholinergic mechanism..Flurbiprofen inhibits miosis induced during the course of contaract surgery.

Indications

Postoperative & post laser inflammation of the anterior segment of the eye. Inhibition of intraoperative miosis.

Dosage

1 drop every 1/2 hr. in the eye (S) begining 2-3 hrs. before surgery. Post surgicalprocedures : 1 drop every 4 hrs in the eye (S) for 1-3-wks.

Contra-Indications

Epithellal herpes simplex keratitis (Dendritis keratitis). Hypersensivity to any component.

Special Precautions

-Use with caution in individuals with a history of gastrointestinal disorders, cardiovascular disease, or renal impairment. -Monitor for signs of gastrointestinal bleeding or ulcers. -Use the lowest effective dose for the shortest duration necessary. -Consider alternative pain management strategies for long-term use.

Side Effects

Transient burning & stinging, ocular irriation. increased bleeding tendency of ocular tissues in conjunction with surgery.

Drug Interactions

-May interact with anticoagulants (e.g., warfarin), other NSAIDs, and certain antihypertensives. -Use caution when combined with medications that affect liver or kidney function.