Niacinamide

Niacinamide, also known as nicotinamide, is a form of vitamin B3. It is an essential nutrient that supports many cellular processes, including energy production, DNA repair, and cell signaling. Niacinamide is widely used in skincare products for its anti-inflammatory and antioxidant properties.

Indications

-Treatment of pellagra, a condition caused by niacin deficiency -Management of acne and other inflammatory skin conditions -Improvement of skin barrier function -Reduction of fine lines and wrinkles -Hyperpigmentation treatment

Dosage

-For Pellagra: 300 mg per day, divided into smaller doses. -For Acne and Skin Conditions: Topical applications in concentrations ranging from 2% to 10%, applied once or twice daily. -Dietary Supplement: 14-16 mg per day for adults, as part of a balanced diet.

Contra-Indications

-Known hypersensitivity to niacinamide or any component of the formulation. -Severe liver disease (when taken in high oral doses).

Special Precautions

-Use with caution in patients with liver disease when taken orally in high doses. -Monitor blood glucose levels in diabetic patients, as niacinamide may affect blood sugar control. -Pregnant or breastfeeding women should consult a healthcare provider before using high doses.

Side Effects

-Oral: Nausea, headache, dizziness, and liver toxicity at high doses. -Topical: Mild burning, itching, redness, or irritation at the site of application.

Drug Interactions

-Can enhance the effects of blood sugar-lowering medications. -May interact with cholesterol-lowering drugs (statins), increasing the risk of side effects like muscle pain and liver damage. -May interfere with certain blood thinners (anticoagulants).