Tapentadol hydrochloride
Tapentadol Hydrochloride is a centrally acting analgesic with dual mechanisms of action—?-opioid receptor agonism and norepinephrine reuptake inhibition. It is used to manage moderate to severe acute and chronic pain, offering effective relief with a lower incidence of gastrointestinal side effects compared to traditional opioids.-Moderate to severe acute pain -Chronic musculoskeletal pain -Pain associated with diabetic peripheral neuropathy -Postoperative pain (short-term use)
(Dosage may vary by country, formulation, and patient condition; follow medical guidance.) -Immediate-release: Typically 50 mg, 75 mg, or 100 mg every 4–6 hours as needed. -Extended-release: Usually 50–250 mg twice daily. Maximum daily dose depends on patient evaluation and regulatory guidelines.
Tapentadol Hydrochloride is contraindicated in: -Severe respiratory depression -Acute intoxication with alcohol, hypnotics, or CNS depressants -Paralytic ileus -Patients with known hypersensitivity to tapentadol -Severe bronchial asthma without available resuscitative equipment
-Use with caution in patients with respiratory disorders. -Risk of dependence, tolerance, and misuse. -May cause dizziness and impair ability to drive or operate machinery. -Monitor patients with hepatic or renal impairment. -Avoid use in pregnancy and breastfeeding unless clearly necessary. -Caution in elderly due to increased sensitivity. -Cause CNS depression so use carefully in drivers and machine operators, may cause billiary spasm, avoid CNS depressant along with it, chance of Dependence and abuse, head injury. Pregnancy: Category C. Not to be used during labor it can cause respiratory depression in newborn. Lactation : Not recommended. Children : Safety and efficacy not established. Ederly : Use with lower dose.
Nausea, dizziness, vomiting, somnolence, constipation, pruritus, dry mouth, hyperhydrosis, fatigue.
MAO Inhibitors, triptans, SSRIs, SNRIs, TCAs, alcoho
